Consolidating industry need that
The standard model of synaptic consolidation suggests that alterations of synaptic protein synthesis and changes in membrane potential are achieved through activating intracellular transduction cascades.
LTP, one of the best understood forms of synaptic plasticity, is thought to be a possible underlying process in synaptic consolidation.When interpreted in the context of synaptic consolidation, mechanisms of synaptic strengthening may depend on the spacing of memory reactivation to allow sufficient time for protein synthesis to occur, and thereby strengthen long-term memory.Protein synthesis plays an important role in the formation of new memories.The case of Henry Molaison, formerly known as patient H.M., became a landmark in studies of memory as it relates to amnesia and the removal of the hippocampal zone and sparked massive interest in the study of brain lesions and their effect on memory.Memory consolidation was first referred to in the writings of the renowned Roman teacher of rhetoric Quintillian. that the interval of a single night will greatly increase the strength of the memory,” and presented the possibility that “… undergoes a process of ripening and maturing during the time which intervenes.” The process of consolidation was later proposed based on clinical data illustrated in 1882 by Ribot’s Law of Regression, “progressive destruction advances progressively from the unstable to the stable”. Burnham a few years later in a paper on amnesia integrating findings from experimental psychology and neurology.
Coining of the term “consolidation” is credited to the German researchers Müller and Alfons Pilzecker who rediscovered the concept that memory takes time to fixate or undergo “Konsolidierung” in their studies conducted between 18.
The two proposed the perseveration-consolidation hypothesis after they found that new information learned could disrupt information previously learnt if not enough time had passed to allow the old information to be consolidated.
Systematic studies of anterograde amnesia started to emerge in the 1960s and 1970s.
The result of the gene expression is the lasting alteration of synaptic proteins, as well as synaptic remodeling and growth.
In a short time-frame immediately following learning, the molecular cascade, expression and process of both transcription factors and immediate early genes, are susceptible to disruptions.
Disruptions caused by specific drugs, antibodies and gross physical trauma can block the effects of synaptic consolidation.