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The laboratory assessments were performed every 4 weeks.Microvascular endothelium-dependent and endothelium-independent vasodilation was evaluated with laser Doppler fluxmetry (LDF) combined with iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) as described previously [].

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In this single center, open study, 15 patients with limited cutaneous SSc were treated with bosentan for 16 weeks with a follow-up period of 4 weeks.The Raynaud’s Condition Score improved from 4.8 ± 2.6 at baseline to 2.7 ± 2.1 after 16 weeks of treatment (].We hypothesized that the beneficial effects of bosentan in the prevention of digital ulcers and maybe also, as suggested in our previous study, in SSc-associated RP could be explained by its effects on microvascular structure and function in this condition.(more tags) #asian #squirt #hairy #bbw #milk #anal #pregnant #milf #18 #bigboobs #feet #ohmibod #french #ebony #teen #german #mature #young #lovense #mistress #office #pantyhose #dirty #latina #c2c #new #redhead #bigass #daddy #shhh #slave #cum #joi #bigtits #bdsm #lesbian #smalltits #deepthroat #curvy #taboo #petite #smoke #tokenkeno #fetish #ass #torture #pussy #indian #schoolgirl #hairypussy #work #daughter #chubby #lush #heels #humiliation #cei #stockings #skinny #mommy This website contains information, links, images and videos of sexually explicit material (collectively, the “Sexually Explicit Material”).Do NOT continue if: (i) you are not at least 18 years of age or the age of majority in each and every jurisdiction in which you will or may view the Sexually Explicit Material, whichever is higher (the “Age of Majority”), (ii) such material offends you, or (iii) viewing the Sexually Explicit Material is not legal in each and every community where you choose to view it. Briefly, after a baseline recording of 5 min at rest (baseline flux), iontophoresis was started by setting time and current strength based on previously documented and accepted protocols of multiple fixed doses [].

ACh response was measured at the dorsal side on the middle phalanx of the third finger of the dominant hand and SNP on the same site on the nondominant hand. The mean flux of the first 5 min excluding moving artifacts made up the baseline flux.

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The endothelium-derived vasoconstrictor molecule endothelin-1 (ET-1) has been suggested to play a role in the pathogenesis of Raynaud’s phenomenon (RP) and systemic sclerosis (SSc).

Patients were not eligible in case of digital ulcers due to other conditions than SSc, prostanoid therapy during the last month, sympathectomy of the upper limb performed within 12 months before study entry, current smoking or smoking within 4 weeks before study entry, and any other severe concurrent illness.

All patients had to provide written informed consent.

Ethical approval for the study was obtained from the Medical Ethical Committee of the University Medical Center Groningen, The Netherlands.