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Sedating older equines

At higher doses it may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes.Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect.

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Sedatives — most commonly alcohol — have been reported for their use as date rape drugs (also called a Mickey) and being administered to unsuspecting patrons in bars or guests at parties to reduce the intended victims' defenses. Statistical overviews suggest that the use of sedative-spiked drinks for robbing people is actually much more common than their use for rape., as the loss of inhibitions from the drug may increase their confidence to commit the offence, and the amnesia produced by the drug makes it difficult for police to interrogate them if they are caught.About half of all the people admitted to emergency rooms in the U. as a result of nonmedical use of sedatives have a legitimate prescription for the drug, but have taken an excessive dose or combined it with alcohol or other drugs.There are also serious paradoxical reactions that may occur in conjunction with the use of sedatives that lead to unexpected results in some individuals.Both physical and psychological dependence can be treated with therapy. Many sedatives can be misused, but barbiturates and benzodiazepines are responsible for most of the problems with sedative use due to their widespread recreational or non-medical use.People who have difficulty dealing with stress, anxiety or sleeplessness may overuse or become dependent on sedatives.There is some overlap between the terms "sedative" and "hypnotic".

Advances in pharmacology have permitted more specific targeting of receptors, and greater selectivity of agents, which necessitates greater precision when describing these agents and their effects: Doctors often administer sedatives to patients in order to dull the patient's anxiety related to painful or anxiety-provoking procedures.

Sedatives and alcohol are sometimes combined recreationally or carelessly.

Since alcohol is a strong depressant that slows brain function and depresses respiration, the two substances compound each other's actions and this combination can prove fatal.

Like alcohol, benzodiazepines are commonly used to treat insomnia in the short-term (both prescribed and self-medicated), but worsen sleep in the long-term.

While benzodiazepines can put people to sleep but, while asleep, the drugs disrupt sleep architecture: decreasing sleep time, delaying time to REM sleep, and decreasing deep slow-wave sleep (the most restorative part of sleep for both energy and mood).

The long-term use of benzodiazepines may have a similar effect on the brain as alcohol, and are also implicated in depression, anxiety, posttraumatic stress disorder (PTSD), mania, psychosis, sleep disorders, sexual dysfunction, delirium, and neurocognitive disorders (including benzodiazepine-induced persisting dementia which persists even after the medications are stopped).